Mutations that increase the endocannabinoid anandamide decreased pain, but did not eliminate as completely as mutations in Nav1.7

Charlotte’s Web is a cannabis strain with high cannabidiol (CBD) used to treat children with epilepsy.

The endocannabinoids anandamide and 2-AG act as retrograde neurotransmitters in synaptic plasticity and memory formation, anxiety and pain.

THC, CBD and other cannabinoids found in marihuana act through CB1, CB2 and GPR55 receptors.