Mutations that increase the endocannabinoid anandamide decreased pain, but did not eliminate as completely as mutations in Nav1.7

Charlotte’s Web is a cannabis strain with high cannabidiol (CBD) used to treat children with epilepsy.

The endocannabinoids anandamide and 2-AG act as retrograde neurotransmitters in synaptic plasticity and memory formation, anxiety and pain.

THC, CBD and other cannabinoids found in marihuana act through CB1, CB2 and GPR55 receptors.

Neurons process information as excitatory and inhibitory postsynaptic potentials in dendrites that generate action potentials in the axon.